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While gastrointestinal side effects such as nausea were common, they were mild and temporary

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The FDA recommends using backup contraception or switching to non-oral methods for four weeks after initiating tirzepatide and for four weeks following each dose escalation to ensure contraceptive reliability during periods of maximum gastric emptying effects

Switching back to mammalian models (hamster, rats, pigs), researchers found that GLP-1 could stimulate insulin secretion and inhibit glucagon release, which could vastly benefit diabetic patients

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