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Common side effects of semaglutide are mild and include nausea or digestive discomfort, which usually improve over time

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However, appropriate surgical planning requires a deeper understanding of how GLP-1 RAs-induced rapid weight loss affects collagen and elastin synthesis, the extracellular matrix, and wound healing dynamics

In the animal models utilized in the Penn Medicine Long COVID study, researchers found that providing serotonin-depleted subjects with direct serotonin precursors like 5-HTP successfully supported their memory and cognitive function

These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance