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While initially a consequence of oxidative damage, this downregulation appears to reflect a protective response aimed at minimizing further ROS generation

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doi: 10.1016/s1566-0702(01)00311-3

The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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Curr Allergy Asthma Rep 14(1):404