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6 In obesity without diabetes (a 72-week trial, ~3,127 participants), mean body-weight change reached roughly 7.5%, 8.4%, and 11.2% at 6, 12, and 36 mg versus about 2.1% with placebo on the treatment-regimen estimand, with the highest dose reaching approximately 12.4% (about 27 lb) on the efficacy estimand, accompanied by improvements in cardiometabolic risk markers

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Signs of a degraded or contaminated solution include: cloudiness that won't clear, visible particles or flakes, unusual discoloration, or a foul odor

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

In the UK, it is available over-the-counter and is commonly recommended as a first-line treatment for mild to moderate pain and fever