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However, cellular function involves more than energy production alone

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Phase I and II clinical trials conducted have shown improved cognitive and motor function with different drugs from GLP-1RA group although the small sized and limited duration of trials have not provided a conclusive result to influence the practice, although with further advancement in ongoing trials effects observed may be noteworthy for intervention in future practice (119)

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Given that over 40% of all methylation goes to the production of creatine, this would be consistent with this mechanism (see Mutations in the enzyme GAMT are associated with conditions such as autism