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PfGrx shares 39% sequence identity with human Grx1, including a CPYC motif and a semiconserved GGC motif, and is well characterized in vitro and in roGFP2 assays in yeast 14,26,30,35

(1993) investigated IGF-1 LR3 in animal models and demonstrated that its reduced IGFBP binding resulted in enhanced bioactivity compared to native IGF-1 at equivalent doses [2]

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Both peptides trigger this release through the growth hormone secretagogue receptor (GHS-R) not the normal growth hormone-releasing hormone (GHRH) pathway

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