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Numerous studies have also shown how important the portal glucose sensor is in maintaining glucose homeostasis and how GLP- 1 receptors are related to portal glucose sensing, with GLP- 1 being required for portal glucose to trigger the insulin response

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The self-association of liraglutide leads to delayed absorption into systemic circulation, which was observed in clinical studies where intravenously administered liraglutide was found to have a shorter residence time than when administered subcutaneously [66, 67]