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Studies have shown that peptide drugs can denature or degrade when exposed to temperatures outside the recommended ranges

[DOI] [PMC free article] [PubMed] [Google Scholar] Buwalda F., Stulen I., de Kok L., Kuiper P.J.C

The discontinuation guide covers this topic comprehensively

[DOI] [PubMed] [Google Scholar] 18.Rebouche C.J