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Pepsin cleaves the His-D-2-Nal bond, separating the N-terminal dipeptide (Aib-His) from the C-terminal tripeptide (D-2-Nal-D-Phe-Lys-NH2)

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This would imply that therapeutic strategies directed at the gut microbiota may prove effective for treating CKD and its related complications

J Dermatolog Treat 15: 222-226