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doi: 10.3389/fnut.2022.888671 66

N Engl J Med 2017;377:64457.PubMed 34

Kharouf F, Gladman DD

MC1R Pathway Melanogenesis Via MC1R engagement, MT-2 activates the Gs/adenylate cyclase/cAMP/PKA pathway in melanocytes, upregulating tyrosinase activity and stimulating eumelanin production the same primary pigmentation mechanism as MT-1, but with additional receptor activity overlapping the broader melanocortin axis