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Vitamin B12 can then be absorbed into the bloodstream via endocytosis in the distal ileum, or by passive diffusion in the absence of intrinsic factor.2 Pernicious anemia (an autoimmune disease) affects the gastric mucosa, leading to destruction of parietal cells and failure to produce intrinsic factor, resulting in vitamin B12 malabsorption and eventually deficiency

When these are cleared, the resulting skin differences become visible

Conclusion The distinction of bacteriostatic water and reconstitution solution such as water for injection (WFI) matters

Cheli et al, 2011

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