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Melanotan is a synthetic peptide synthesized to mimic the action of melanocortins

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Verhulst B, Neale MC, Kendler KS

Trial strengths include the randomized, controlled study design, inclusion of healthy lifestyle counseling throughout the trial, and use of rescue orforglipron in case of significant (50%) weight regain to limit the potential harm associated with weight regain, although this does not allow for pure placebo versus treatment comparison after week 24

Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics [see PRECAUTIONS

In a phase 3 study, participants experienced a remarkable weight loss of up to 15% of their initial body weight, showcasing the drugs potential to significantly impact weight management in individuals with Type 2 diabetes