The lengths of red- and green-labeled fibers were determined by FluoView3.0 software (Olympus)
crenulata and its active metabolites can inhibit the NF-B/NLRP3 pathway to reduce HH-induced brain oxidative stress damage, inflammatory responses, and BBB damage, which are attributed to improved energy metabolism and the anti-inflammatory M2 microglial phenotype ( Rhodiola crenulata and salidroside can exert anti-hypoxia neuroprotective effects by inhibiting neuronal apoptosis, maintaining BBB integrity, increasing tight junction proteins claudin-1, ZO-1, and occludin, and improving mitochondrial morphology and function, possibly through activation of the AMPK/Sirt1 signaling pathway ( Rhodiola crenulata extracts exert antioxidant effects by scavenging lipid peroxidation products (e.g., MDA) and enhancing SOD activity, regulating cell apoptosis and mitochondrial energy metabolism through the HIF-1/microRNA 210/ISCU1/2 (COX10) signaling pathway, and inhibiting caspase-3 activation to improve brain tissue energy metabolism disorders to alleviate HH-induced brain damage ( Crocus sativus is an important component of traditional TM, and its active metabolites crocin demonstrates significant neuroprotective effects in the treatment of HACE
Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model
[DOI] [PMC free article] [PubMed] [Google Scholar] 278.Mao, X
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