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207 Liraglutide treatment was also demonstrated to inhibit beta-cell apoptosis in isolated human pancreatic beta-cells, and after 24 hours, the islet beta-cell proliferation rate tripled

Methionine research primarily comes from animal models examining liver triglyceride regulation

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Whilst mutations of the MC4R are a rare genetic cause of obesity, the treatment of two people with POMC deficiency with the MC4R agonist setmelanotide previously resulted in massive weight loss of 51.0 kg and 20.5 kg over 42 and 12 weeks respectively [97], highlighting the potential of this mechanism to support weight loss in obesity