Prince provides guidance on maintaining the benefits and suggests an appropriate maintenance schedule based on individual needs
Additionally, it shows a greater ability to inhibit tyrosinase activity (an enzyme that produces melanin and causes hyperpigmentation) than other antioxidants used in skin care, such as kojic acid 2
A first-in-human, randomized, double-blind, placebo-controlled phase I study in healthy volunteers (clinical trial ID: NCT05027568) demonstrated that oral IOA-289 was well tolerated with no clinically significant adverse events
Fang Y.-Z., Yang S., Wu G
Importantly, treatment did not negatively impact markers such as bone mineral density (BMD) or body weight in a manner inconsistent with healthy controls (Fawcett 2010)
Available from: [Last accessed on 24 Jul 2017]