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Various inflammation-related regulatory factors (such as NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), Toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1)) are involved in the regulation of heat stress-related SIRS [25]: After heat stimulation in the rat model, NLRP3 combines with pro-caspase-1 and the CARD-containing apoptosis-associated speck-like protein (ASC) to form the NLRP3 inflammasome complex

A systematic evaluation of peripheral cytokines (e.g., via multiplex Luminex assays) will be conducted in follow-up studies to map gut-derived immune signals to CNS pathology

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It strongly suppresses Bcl-xL, Bcl-2, and Bcl-w and disrupts Bcl-xL/Bcl-xS interactions