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The agency also received reports associated with taking doses beyond the FDA-approved label, for example: Using too much product in a single injection Injecting more often than recommended Increasing the dose too rapidly Gastrointestinal Adverse Events and Dosing Caution for Compounded Products Reported symptoms have included: Nausea Vomiting Diarrhea Abdominal pain Constipation Some patients sought medical care Health care providers should be careful when prescribing compounded semaglutide or tirzepatide and when setting titration and dosing schedules

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Lastly, although the use of analytical methods has aided in our deeper understanding of the relationship between drugs and ADEs, it must be emphasized that well-designed clinical trials remain crucial in establishing causal relationships, and further research needs to be conducted through extensive clinical studies

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