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Molecules 26:2059 Kakde D, Jain D, Shrivastava V, Kakde R, Patil A (2011) Cancer therapeutics-opportunities, challenges and advances in drug delivery

Preclinical studies have demonstrated that both glycyrrhizin and silymarin exert hepatoprotective effects against oxidative stress, and their combination may produce synergistic benefits by reducing serum transaminases and enhancing antioxidant enzyme activities (Minsart et al., 2020)

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Therefore, a true overdose that causes toxicity is extremely rare

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doi:10.1074/jbc.M112.355172 Wood, J M et al