The Phase 2b trial used subcutaneous injection, not oral formulation
In various animal models of anxiety disorders, centrally injected CRF induces anxiety-like responses such as sleep disturbances, loss of appetite, and anhedonia (143)
Midorikawa S, Sanada H, Hashimoto S, and Watanabe T (2000)
The second formula you need determines how much solution to draw for any given dose: Volume to Draw (mL) = Desired Dose (mg) / Concentration (mg/mL) Want 2.5mg from that 5mg/mL solution
ASN Neuro 13, 17590914211037505
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