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10.1074/jbc.M110.164806 29 DixonD

Poor storage can reduce potency and increase the risk of contamination, which directly affects both safety and effectiveness

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The enhancement of viral infectivity could be attributed to the hypomethylation of STAT1, leading to a reduced binding of STAT1 to the interferon-stimulated response element and thus reduction of the expression of interferon-stimulated genes (ISGs), weakening the antiviral effects of interferon (78, 79)