A complete clinical picture requires accounting for the other hormones whose decline shapes how both therapies perform in practice, and in some cases, how effectively they protect the very systems this section has been examining
The SUSTAIN-6 trial of semaglutide demonstrated a reduction in major adverse cardiovascular events (MACE) in patients with type 2 diabetes and established cardiovascular disease
Secondary Outcome: Secondary Outcomes: Changes in waist circumference, body fat, body lean mass, and metabolic risk factors including levels of plasma glucose, insulin sensitivity, serum lipids, and blood pressure Statistical Analysis Full details previously published 2 and can also be found in the STEP group statistical analysis plan at NEJM.org Statistical analysis approach sought strong control for type I error All endpoints addressing intervention efficacy were analyzed using intention-to-treat approach All endpoints addressing intervention safety were analyzed using per-protocol approach Efficacy endpoints analyzed using 2 estimands Treatment Policy Estimand: intention to treat analysis
Pharmaceutics 17(3):388 Bufarwa SM et al (2025) Anticancer activity, DFT, molecular docking, ADMET, and molecular dynamics simulations investigations of Schiff base derived from 2,3-diaminophenazine and its metal complexes
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