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The impact of saffron (Crocus sativus) supplementation on visual function in patients with dry age-related macular degeneration

Molecular investigations were performed for TRPV1, NR2B, neuro-inflammatory and glia cell markers (TNF-, IL-6, Iba-1 & ICAM-1), and neuropeptides (CGRP), using western blotting and RT-PCR analysis

The molecular mechanism involves the PI3K/AKT1 pathway, a major cell survival signaling cascade

Mechanistic human studies propose a GLP-1 kidney axis that helps control kidney function and fluid balance

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