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Because many people who receive chemotherapy have primary or secondary resistance to it, the treatment does not work as effectively as it should (92)

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23 In addition to autoregulatory feedback loops, polyubiquitination regulates the stability of the p53 family of proteins through a series of E3 ubiquitin ligases divided into three subfamilies: the Homologous to E6-AP Carboxyl Terminus (HECT) domain-containing E3s, the Really Interesting New Gene (RING) finger domain-containing E3s, and the U box E3s

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As new therapeutic agents for AD continue to develop 3,4 , timely diagnosis and accurate patient selection for these treatments are becoming increasingly important