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It requires a safe, medically sound, and supportive approach

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Furthermore, the profound osteogenic properties of FMT treatment, which appear to entirely remodel the mouse immune-microbiome ecosystem, are not yet applicable for human OP intervention due to safety and regulatory concerns

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Response: We appreciate commenters' concerns and the varying range of estimates provided by commenters suggests that hospitals have different operational and administrative processes and systems that impact the projected burden of encoding the new data elements and meeting the requirement to update the MRF annually

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