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Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function
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However, an uncontrolled increase in their concentrations leads to a chain of unwanted radical reactions that target the main biomolecules (DNA, RNA, lipids, and proteins) and alters key processes such as nucleic acid oxidation, lipid peroxidation, thereby contributing to the loss of cellular architecture, to impaired cell signalling and, ultimately, to cell death [25, 46]
Zhang Y, Du X, He Z, Gao S, Ye L, Ji J, et al
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