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GPR43 is distributed in adipose tissue, bone marrow, spleen, pancreas, peripheral blood mononuclear cells, small intestine, and mammary gland, while GPR41 is distributed in various tissues, especially in immune cells
That means your body gets more of what youre paying forand it actually reaches the cells that need it
These signals are described as indicators that intake may not be meeting the bodys current needs
There is no clinical trial data comparing split versus single weekly dosing for semaglutide specifically, so this falls into the category of community-derived optimization
Bottom Line Feeling cold on semaglutide is frustrating, but it makes sense once you understand what is happening