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Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice

In addition, S -nitrosylation of the Cys215 residue by NO donors shields PTP1B from subsequent hydrogen peroxide-induced irreversible oxidation (88)

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none of these pathway effects survived FDR correction (Fig

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