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USA 106 , 2193021935 (2009)

Moreover, species differences in ethanol metabolism (e.g., higher catalase activity in rodents) and receptor subtype distribution (e.g., GABAA -subunits) necessitate cautious extrapolation to humans

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By consolidating mechanistic insight, clinical validation, safety profiling, pharmacokinetic challenges, and translational strategies into a unified model, this manuscript aims to provide an evidence-based and clinically actionable framework that extends beyond prior narrative summaries