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KaplanEShifeldrimAKrausDWeissbachAKadmonGMilkhRet alIntranasal dexmedetomidine vs

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Clinical trials confirmed no effect on serum IGF-1, no negative impact on carbohydrate metabolism, and excellent tolerability with safety profile indistinguishable from placebo

It also influences the intestinal microbiota, linked to inflammatory bowel diseases and colon cancer (66)

2 Materials and Methods This systematic review and meta-analysis has been performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Hutton et al., 2015)