Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
Metabolomic studies in the preclinical ischemic AKI model have shed substantial light on this issue and demonstrated widespread changes in energy metabolism in the kidney as well as remote organs including the heart and lung 6,15, 16
These statements have not been evaluated by the Food and Drug Administration (FDA)
Glutathione is a naturally occurring antioxidant produced in the liver
Conversely, a retrospective analysis reported fewer adverse reactions, improved QoL, and longer survival with NAC 600 mg TID + pirfenidone versus pirfenidone + budesonide (143)
Data availability Data generated and analyzed in this study are included in the paper and the Supporting Information (supplementary Figures 1-7 and legends), and are also available to interested person from the corresponding author upon reasonable request