[PubMed] Hathaway CK, Agarwal N, Planas LG, et al
Myostatin is a member of the transforming growth factor beta (TGF) superfamily of growth factors that regulates catabolism of skeletal muscle 9,10,11 , making it an attractive target for muscle atrophy and for preserving muscle during pharmacologic weight loss 12,13
So, if youre not losing weight on tirzepatide, it may be worth taking a closer look at other treatments in your regimen
A 2023 review in Cells described these agents as promising therapies across cardiovascular, renal, neurodegenerative, and metabolic conditions, while noting that the relative contribution of direct cellular effects versus improved cardiometabolic regulation remains under investigation [4]
Meanwhile, the deal mentioned that starting doses of GLP-1 pills will cost $149
Ann Surg 2025;281:600607.ArticlePubMed 41