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Nrf2 also activates the genes encoding the four major NADPH producing enzymes, G6PD, PGD, ME1, and IDH1, for reducing oxidized glutathione and other cellular components

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Research on obese mice suggests that unimolecular poly-pharmacology is an effective means to deal with various mechanisms leading to obesity and further indicates that GCGR activation is the distinguishing factor between single or double agonists and triple agonists of incretin receptors (127)

Fluoxetine is a strong CYP2D6 inhibitor, and bupropion also inhibits CYP2D6