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Topical methimazole, although not allowed in cosmetics, did not induce melanotoxicity or changes in thyroid functions [78, 98], and was proven to be a useful alternative treatment in some melasma cases [97]

In the SURMOUNT-1 clinical trial, gastrointestinal adverse events were the most commonly reported side effects across all dose groups

Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth

Together, it can be concluded that intracellular selenium status (hydrogen selenide) regulates the expressions of seleno-GPxs primarily at the translation level by controlling the stability of their mRNAs as well as by facilitating the biosynthesis and subsequent incorporation of Sec into the peptide sequence (Fig

10.1172/JCI116186 154

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