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For instance, NCOA4-mediated ferritinophagy may impact the activity of glutathione peroxidase 4 (GPX4), as increased iron levels can deplete intracellular antioxidants like glutathione, indirectly inhibiting GPX4 function and thereby facilitating ferroptosis (Mancias et al., 2014)

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The higher dose of 0.14 mol/kg had even greater effects, with less than 25% of radioactivity remaining in the stomach after 15 minutes

GSH is a cofactor, coenzyme, and/or substrate for a number of enzymes and can participate in a number of redox and conjugation reactions

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FDAs Q2(R2) guidance identifies analytical validation concepts such as specificity, accuracy, precision, and range, which belong to method and data review rather than calculator interpretation [2]