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The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place

The National Academies of Sciences, Engineering, and Medicine recommend: People ages 14 and older get 2.4 mcg of B12 per day Pregnant individuals get 2.6 mcg of B12 per day Breastfeeding individuals get 2.8 mcg of B12 per day There hasn't been a tolerable upper intake level set for B12

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