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Rather than suppressing the entire immune response, these peptides can potentially shift the balance between pro-inflammatory and anti-inflammatory processes, promote regulatory T cell function, and restore tolerance mechanisms that have broken down in lupus

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Arstall MA, Yang J, Stafford I, Betts WH, Horowitz JD

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In particular, engineered living bacteria modified by genetic engineering or chemical materials can deliver PD-L1 and CTLA-4 in tumors to promote the treatment of diseases [137]

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