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Previous results indicate that TNC is downregulated by GLP-1RA treatment and correlates with incident CVD 43 , suggesting that TNC may act as a mediator, with downregulation contributing to the cardiovascular-protective effects of GLP-1RAs

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However, since early 2025, in the United Kingdom, people who meet certain BMI criteria and have at least one weight-related co-morbidity have been able to access semaglutide ( Wegovy ) and tirzepatide ( Mounjaro ) for weight management

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