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Journal of Nutrition, 2004.

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In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29

DSIP administration did not significantly affect corticotropin-releasing-hormone (CRH)-stimulated or meal-induced ACTH and cortisol secretion, indicating thatcontrary to stress-protective effects reported in some animal studiesDSIP does not measurably blunt the human cortisol response

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