Cyclic AMP determination To measure intracellular cAMP concentrations, H9c2 cells and NMCMs were pretreated with 3-isobutyl-1-methylxanthine (0.1 mM, IBMX, Sigma-Aldrich) for 30 min and then stimulated with the non-selective MC-R agonist -MSH (0.1 nM) or the MC5-R agonist PG-901 (0.1 nM) for 5, 15, 30, and 60 min

Mid-Morning Snack A small apple with a few almonds Plain crackers with a thin slice of turkey Carrot sticks with hummus Lunch Ideas Option 1: Grilled chicken on a bed of mixed greens with olive oil dressing Option 2: Vegetable soup with a side of whole grain crackers Option 3: Tuna salad (made with light mayo) on whole wheat bread Afternoon Snack Greek yogurt A pear or a handful of berries A small smoothie with spinach, banana, and protein powder Dinner Ideas Option 1: Baked salmon with roasted broccoli and brown rice Option 2: Turkey breast with sweet potato and steamed green beans Option 3: Tofu stir-fry with lots of colorful vegetables Evening (If Hungry) Ginger tea A few whole grain crackers Small handful of berries Eating Tips That Make a Difference Chew Your Food Well Take your time eating
Reduces Hyperpigmentation: Promotes a more even skin tone by supporting melanin regulation
Current medical guidelines for resuming tirzepatide after surgery are evolving as clinical experience with GLP-1/GIP receptor agonists in the perioperative setting accumulates
Tanya Kormeili is a nationally recognized, board-certified dermatologist and Clinical Professor of Dermatology at UCLAs David Geffen School of Medicine
doi: 10.1084/jem.20192195 138 WangXOtaNManzanilloPKatesLZavala-SolorioJEidenschenkCet al