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However, we found that both Alanine and Cystine substantially fell outside of healthy reference ranges, with Cystine being dramatically reduced in both affected and unaffected siblings with average plasma concentrations of 3.0 mol/L and 3.3 mol/L respectively, while Alanine was found to be elevated regardless of disease status (U:595.5 mol/L, K:589.0 mol/L)

Metabolites were putatively identified using database search against the ECMDB ( Multivariate analysis was performed using MetaboAnalyst 5.0 ( and EZinfo software (Waters, Milford, MA, USA)

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This high overall GI rate (while mostly mild) likely reflects the combined GI effects of activating both GLP-1 and amylin pathways simultaneously

Moldeus P: Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse