| Substance | Receptor profile | Trial | Weight change | Placebo | | --- | --- | --- | --- | --- | | Retatrutide | GIP/GLP-1/glucagon | Phase 2 (48 wk) | -8.7 to -24.2 % | -2.1 % | | Tirzepatide | GIP/GLP-1 | SURMOUNT-1 (72 wk) | -16.0 to -22.5 % | -3.1 % | | Semaglutide | GLP-1 | STEP 1 (68 wk) | -14.9 % | -2.4 % | | Cagrilintide + semaglutide | Amylin + GLP-1 | Phase 1b (20 wk) | -15.7 to -17.1 % | -9.8 %* | | CagriSema | Amylin + GLP-1 | REDEFINE 1 (68 wk) | -20.4 % | -3.0 % | *Comparator arm semaglutide alone
Annu Rev Biochem 52:711760 Mendoza-Cozatl DG, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI (2008) Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus
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Ren Y, Liu Q, Liu H, Zhou X, Zhang Y, Cai M (2020) Engineering substrate and energy metabolism for living cell production of cytidine-5-diphosphocholine
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