Other mechanisms that sustain AR action under ADT include expression of AR from ecDNAs or induction of the structurally related nuclear receptor glucocorticoid receptor (GR) that can take over control over at least a fraction of the AR-dependent cistrome and transcriptome [37,38,39]
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We looked at brain perfusion, glucose uptake, and fatty acid uptake and presented this data earlier this year at EASD 2023
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