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GLP-1 receptor agonists have revealed notable weight loss outcomes, leading to their increasing use beyond diabetes care

doi: 10.1038/nature08821 2 BrandiGFregaG

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It has an amino acid substitution at position 8 (Aib instead of Ala) to prevent DPP-4 cleavage, and a C-18 fatty acyl chain with a spacer attached at Lysine 26, which gives it strong albumin binding (even more than liraglutides C-16) ( [111] ) ( [48] )

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