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Thus, the activation of the innate immune system plays a key role in the onset and progression of vitiligo, largely by creating a pro-inflammatory microenvironment and orchestrating the activation and recruitment of pathogenic CD8 + T cells

However, the most important pathway in psoriasis pathogenies is activation of Th17 cells in the presence of IL-6 and TGF

This effect is reversed by the treatment with dulaglutide (Guan et al., 2022)

Satoh K, Kitahara A, Sato K

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Tirzepatide typically produces 15-22% weight loss, well above this threshold