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Overall, the combined observations of these early studies, together with more recent evidence, suggest that alpha-cells are capable of processing and secreting active GLP-1

no significant heterogeneity was found in studies belonging to the diabetes subgroup

Furthermore, TMAO induces reactive oxygen species (ROS) generation in macrophages, creating a feed-forward loop that amplifies both inflammatory responses and oxidative stress ( 4.2 Impact of TMAO on DCs DCs, as the most potent professional antigen-presenting cells in the body, play a pivotal role in antigen recognition and signal transmission during immune response

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The data emerging from the most recent reviews and meta-analyses on vitamin D and vitamin B12 in relation to thyroid function and autoimmunity are summarized in Table 1