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Blueberries impact on insulin resistance and glucose intolerance

Regulation in mRNA and protein levels and phosphorylation of many key molecules such as insulin receptor substrate (IRS), protein kinase B (PKB), phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), Jun N-terminal Kinase 1 (JNK), MAPK, and fork-head box O family proteins (FOXO) involved in insulin signaling pathway were observed in diabetic animals treated with polysaccharides extracted from a number of mushrooms such as Grifola frondosa , L

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It makes the molecule more prone to aggregation, the process where peptide molecules clump together and lose their individual functionality

This endogenous activation provides sustained cellular protection compared to direct free radical scavenging by exogenous antioxidants

Particularly, it enhances leptin signaling via leptin receptor-expressing neurons in the brainstem