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More importantly, the downregulation of the EZH2 gene leads to a decrease in LAT1 ( SLC7A5 ) expression, and, in turn, the downregulation of LAT1 ( SLC7A5 ) or the depletion of essential amino acids can also induce a decrease in EZH2 expression (Dann et al., 2015)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Gavett BE, Stern RA, Cantu RC, Nowinski CJ, McKee AC (2010) Mild traumatic brain injury: a risk factor for neurodegeneration