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Evidence From Clinical Trials on Cardiovascular Outcomes Phase 2 data (NEJM 2023) showed systolic blood pressure reductions of approximately 46 mmHg and a modest heart rate increase, but no cardiovascular outcome trial exists for retatrutide and definitive conclusions about cardiovascular benefit or risk cannot yet be made
(PMC) A separate metabolism-focused paper reviewing human trial history makes a similar point: early signals of weight loss were not consistently reproduced in later studies, particularly when intensive diet/exercise protocols were included
Lahoz, Carmen Martnez, Joaqun Pea, Luis M
Indocyanine green lymphangiography (ICG) demonstrated mild abnormal collateralization of lymphatic vessels and presence of lymphatic pumping and flow into the axilla