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Primarily summarized into 3 main MOA: MOA: Increases Insulin release/sensitivity, decreases glucagon release MOA: Slows gastric emptying (gastric peristalsis) MOA: Appetite Suppression Patho 101: Plasma glucose is maintained by a tug-of-war between the hypoglycemic effect of insulin and the hyperglycaemic effect of glucagon

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Most GLP-1 agonists have simpler structures focused on single-receptor optimisation, whereas Retatrutides design accommodates multi-receptor binding requirements

Retrieved from Lynch, J., et al