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However, stacking it directly with exogenous GH is usually unnecessary since both target the same pathway and may increase risk of side effects

Endogenous pathways encompass the production of ROS due to mitochondrial dysfunction, endoplasmic reticulum stress, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, lysosomal activity, and the activation of metabolic enzyme systems, including cytochrome P450 monooxygenases, lipoxygenases, and cyclooxygenases

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